ArticleSchein PS, Lavin PT, Moertel CG, Frytak S, Hahn RG, O'Connell MJ, Reitemeier RJ, Rubin J,
... Show More Schutt AJ, Weiland LH, Kalser M, Barkin J, Lessner H, Mann-Kaplan R, Redlhammer D, Silverman M, Troner M, Douglass HO, Milliron S, Lokich J, Brooks J, Chaffe J, Like A, Zamcheck N, Ramming K, Bateman J, Spiro H, Livstone E, Knowlton A.Cancer. 1978 Jul;42(1):19-22.
Sixty-six patients with advanced pancreatic carcinoma were randomized to receive single agent chemotherapy with either adriamycin, methotrexate, or actinomycin-D using conventional dose, route and schedule of administration. All patients had measurable lesions which were used to objective assessment of response. For adriamycin, 2 of 25 patients (8%) evidenced a partial response (2 of 15 (13%) previously untreated patients). One of 25 patients treated with methotrexate and one of 28 received actinomycin-D responded. The duration of responses ranged from 43-64 days for those patients with no chemotherapy prior to study entry. The median survival of patients who received adriamycin as initial treatment was 12 weeks compared to 8 weeks for methotrexate and 6 weeks for actinomycin-D therapy.